Last Revised: March 11, 2020

Revision 3/2020 (original)

The requirements in Penn's Chemical Hygiene Plan SOP:  Acutely Toxic Chemicals apply to all work involving p-listed chemicals.  The Fact Sheet below gives disposal guidance for these chemicals and empty containers; however, this information is provided as a supplement to the SOPs and the Chemical Waste Guidelines, as well as any other applicable SOPs and Fact Sheets for the chemical hazards.


Chemicals that are listed by the EPA as acutely hazardous ‘P-listed’ chemicals have special disposal requirements.

  1. Unwanted reagents:  Unused or unwanted containers of P-listed chemicals must be managed as a hazardous waste and disposed through EHRS.  Since the container is also hazardous waste (see #2 below) EHRS will accept the surplus reagent in its original container as hazardous waste.
  2. Empty Containers:  Empty containers that previously held P-listed chemicals must be managed as hazardous waste and given to EHRS for disposal.  DO NOT TRIPLE RINSE or re-use these containers. 
  3. Broken bottles, spill cleanup:  Broken bottles of P-listed chemicals must be managed as hazardous waste along with all contaminated items used to clean up the spill.  (Contact EHRS for assistance for any spills of p-listed or other acutely toxic chemicals.)

Top Five Most Common P-Listed Chemicals at Penn

In Biomedical Labs In Physical Science Labs

Sodium azide

Sodium azide

Potassium cyanide

Copper cyanide


Carbon disulfide

Osmium tetroxide

Propargyl alcohol

Sodium cyanide

Sodium cyanide

Click here for a complete list of P-Listed chemicals.

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